Dehydrochlorination Mechanism of DDT Analogs Catalyzed by Housefly Enzyme
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Theoretical Study of the Mechanism of Exemestane Hydroxylation Catalyzed by Human Aromatase Enzyme.
Human aromatase (CYP19A1) aromatizes the androgens to form estrogens via a three-step oxidative process. The estrogens are necessary in humans, mainly in women, because of the role they play in sexual and reproductive development. However, these also are involved in the development and growth of hormone-dependent breast cancer. Therefore, inhibition of the enzyme aromatase, by means of drugs kn...
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Equations 2 and 3, came from investigations with a highly purified enzyme from Micrococcus aerogenes (6), and from experiments with the pigeon liver enzyme (7-9). On the other hand, data (10, 11) obtained with a formate-activating enzyme from Clostridium cylindrosporum have led to an alternate interpretation, namely that Reaction 1 goes via a concerted mechanism without the formation of any det...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1988
ISSN: 0002-1369
DOI: 10.1080/00021369.1988.10868923